Inhibition of serum alkaline phosphatase activity by phenylalanine and cholic acid.

Depression of serum alkaline phosphatase activity by human serum albumin.

The daily intravenous administration of 50 gm. of concentrated saltpoor human serum albumin’ produces a rise in serum albumin level and a decline in urinary calcium and phosphorus excretion (1). These latter changes have been interpreted as evidence for an albumin-induced stimulation of osteogenesis (2). The consistent finding of a concomitant depression of serum alkaline phosphatase activity w...

Skeletal alkaline phosphatase activity in serum.

On the mechanism of inhibition of intestinal alkaline phosphatase by L-phenylalanine. I. Kinetic studies.

The degree of inhibition of rat intestinal alkaline phosphatase by L-phenylalanine was highly pa-dependent and varied from 0 to 66% within a pH range of ‘7.8 to 10.4, exhibiting a peak at pH 9.2 and 8.7 for phenylphosphate and /3glycerophosphate, respectively. Vm,, was also a function of pH with and without the inhibitor. Rat intestinal alkaline phosphatase exhibited maximum enzyme activity at ...

On the Mechanism of Inhibition of Intestinal Alkaline Phosphatase by L-Phenylalanine

The degree of inhibition of rat intestinal alkaline phosphatase by L-phenylalanine was highly pa-dependent and varied from 0 to 66% within a pH range of ‘7.8 to 10.4, exhibiting a peak at pH 9.2 and 8.7 for phenylphosphate and /3glycerophosphate, respectively. Vm,, was also a function of pH with and without the inhibitor. Rat intestinal alkaline phosphatase exhibited maximum enzyme activity at ...

The inhibition of alkaline phosphatase by beryllium.

Recent clinical reports of pulmonary disease occurring in workers in the beryllium industry have stimulated new interest in the biochemical action of this element (for a complete bibliography, see (1)). Although it has not been possible to produce in animals pathological conditions identical with those Eeen in beryllium workers, experimental administration of beryllium and its compounds has res...